This web page was produced as an assignment for Genetics 564, an undergraduate capstone course at UW-Madison.
What is Gene Ontology?
Gene ontology (GO) is a bioinformatics project aimed to bring together all the information known about a gene and its product across different species. Gene ontology provides structured vocabularies for annotation of gene discoveries [1].
GO terms are divided into three main topics: molecular function, cellular component, and biological process. Molecular Function: terms to describe molecular-level activities performed by gene products Cellular Component: terms to describe the cellular location where gene products perform their function Biological Process: terms describing larger processes achieved through multiple molecular activities |
What are GO terms for CRY1?
Molecular Function
The CRY1 protein acts as a transcriptional repressor of the circadian core oscillator complex. |
Cellular Component
The CRY1 protein can be found in the nucleus of all cells in the peripheral clocks and especially at the suprachiasmatic nucleus in the hypothalamus as the central clock whose main function is to control most circadian rhythms in the body. |
Biological Process
Some of the biological processes CRY1 gene is involved in are the regulation of transcription by RNA pol II, DNA damage phosphorylation, circadian rhythm, and light signaling pathways. The CRY1 protein serves as a transcriptional repressor of the feedback loop producing the transcriptional factors CLOCK and BMAL1 that allow for the circadian clocks to restart. |
Conclusion
Gene ontology terms help understand the role of CRY1 in regulating the mechanisms of the circadian rhythm between and within cells. CRY1 helps coordinate the length of a circadian cycle through transcriptional repressing CLOCK and BMAL located within the nucleus of all cells.
References.
1. Gene Ontology project in 2008. (2007, November 04). Retrieved from https://academic.oup.com/nar/article/36/suppl_1/D440/2507489
2. CRY1 Gene - GeneCards | CRY1 Protein | CRY1 Antibody. (n.d.). Retrieved from https://www.genecards.org/cgi-bin/carddisp.pl?gene=CRY1
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1. Gene Ontology project in 2008. (2007, November 04). Retrieved from https://academic.oup.com/nar/article/36/suppl_1/D440/2507489
2. CRY1 Gene - GeneCards | CRY1 Protein | CRY1 Antibody. (n.d.). Retrieved from https://www.genecards.org/cgi-bin/carddisp.pl?gene=CRY1
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Sara Acosta Villarreal Genetics and Genomics, UW-Madison [email protected] Last updated: May 10, 2019 |
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